(+)-Methyl 3?-acet-oxy-13-carb-oxy-19-hy-droxy-11-oxo-C-norolean-18-en-30-oate ?-lactone.

ABSTRACT: The title compound, C(33)H(46)O(7), is an unusual oxydation product of the therapeutic agent glycyrrhetinic acid that has, in comparison to the latter, a distinctly altered triterpene structure with one five- and four six-membered carbocycles complemented by a ?-lactone ring with a spiro-junction and a ring double bond. The junction between the five-membered ring C, a cyclo-penta-none ring, and the six-membered ring D, previously in question, was found to be cis, confirming earlier structure assignments based solely on chemical transformations. In the solid state, the compound exhibits five intra- and four inter-molecular C-H?O inter-actions with H?O distances less than or equal to 2.70?Å and C-H?O greater than 100°.

SUBMITTER: Gaware R 

PROVIDER: S-EPMC2983216 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature