Nucleosome eviction and activated transcription require p300 acetylation of histone H3 lysine 14.

ABSTRACT: Histone posttranslational modifications and chromatin dynamics are inextricably linked to eukaryotic gene expression. Among the many modifications that have been characterized, histone tail acetylation is most strongly correlated with transcriptional activation. In Metazoa, promoters of transcriptionally active genes are generally devoid of physically repressive nucleosomes, consistent with the contemporaneous binding of the large RNA polymerase II transcription machinery. The histone acetyltransferase p300 is also detected at active gene promoters, flanked by regions of histone hyperacetylation. Although the correlation between histone tail acetylation and gene activation is firmly established, the mechanisms by which acetylation facilitates this fundamental biological process remain poor

SUBMITTER: Luebben WR 

PROVIDER: S-EPMC2984149 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature