Relevance of synaptic tagging and capture to the persistence of long-term potentiation and everyday spatial memory.

ABSTRACT: Memory for inconsequential events fades, unless these happen before or after other novel or surprising events. However, our understanding of the neurobiological mechanisms of novelty-enhanced memory persistence is mainly restricted to aversive or fear-associated memories. We now outline an "everyday appetitive" behavioral model to examine whether and how unrelated novelty facilitates the persistence of spatial memory coupled to parallel electrophysiological studies of the persistence of long-term potentiation (LTP). Across successive days, rats were given one trial per day to find food in different places and later had to recall that day's location. This task is both hippocampus and NMDA receptor dependent. First, encoding with low reward induced place memory that decayed over 24 h; in par

SUBMITTER: Wang SH 

PROVIDER: S-EPMC2984182 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature