Electrical detection of pathogenic bacteria via immobilized antimicrobial peptides.

ABSTRACT: The development of a robust and portable biosensor for the detection of pathogenic bacteria could impact areas ranging from water-quality monitoring to testing of pharmaceutical products for bacterial contamination. Of particular interest are detectors that combine the natural specificity of biological recognition with sensitive, label-free sensors providing electronic readout. Evolution has tailored antimicrobial peptides to exhibit broad-spectrum activity against pathogenic bacteria, while retaining a high degree of robustness. Here, we report selective and sensitive detection of infectious agents via electronic detection based on antimicrobial peptide-functionalized microcapacitive electrode arrays. The semiselective antimicrobial peptide magainin I--which occurs naturally on the skin o

SUBMITTER: Mannoor MS 

PROVIDER: S-EPMC2984209 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature