Respiratory virus infection and risk of invasive meningococcal disease in central Ontario, Canada.

ABSTRACT:

Background

In temperate climates, invasive meningococcal disease (IMD) incidence tends to coincide with or closely follow peak incidence of influenza virus infection; at a seasonal level, increased influenza activity frequently correlates with increased seasonal risk of IMD.

Methods

We evaluated 240 cases of IMD reported in central Ontario, Canada, from 2000 to 2006. Associations between environmental and virological (influenza A, influenza B and respiratory syncytial virus (RSV)) exposures and IMD incidence were evaluated using negative binomial regression models controlling for seasonal oscillation. Acute effects of weekly respiratory virus activity on IMD risk were evaluated using a matched-period case-crossover design with random directionality of control selection. Effe

SUBMITTER: Tuite AR 

PROVIDER: S-EPMC2984510 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature