Hepatic microRNA expression is associated with the response to interferon treatment of chronic hepatitis C.

ABSTRACT:

Background

HCV infection frequently induces chronic liver diseases. The current standard treatment for chronic hepatitis (CH) C combines pegylated interferon (IFN) and ribavirin, and is less than ideal due to undesirable effects. MicroRNAs (miRNAs) are endogenous small non-coding RNAs that control gene expression by degrading or suppressing the translation of target mRNAs. In this study we administered the standard combination treatment to CHC patients. We then examined their miRNA expression profiles in order to identify the miRNAs that were associated with each patient's drug response.

Methods

99 CHC patients with no anti-viral therapy history were enrolled. The expression level of 470 mature miRNAs found their biopsy specimen, obtained prior to the combination therapy, we

SUBMITTER: Murakami Y 

PROVIDER: S-EPMC2984584 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature