Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.

ABSTRACT: The Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Phase 1 Schizophrenia trial compared the effectiveness of one typical and four atypical antipsychotic medications. Although trials such as CATIE present important opportunities for pharmacogenetics research, the very richness of the clinical data presents challenges for statistical interpretation, and in particular the risk that data mining will lead to false-positive discoveries. For this reason, it is both misleading and unhelpful to perpetuate the current practice of reporting association results for these trials one gene at a time, ignoring the fact that multiple gene-by-phenotype tests are being carried out on the same data set. On the other hand, suggestive associations in such trials may lead to new hypotheses t

SUBMITTER: Need AC 

PROVIDER: S-EPMC2986499 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature