A gene-based method for detecting gene-gene co-association in a case-control association study.

ABSTRACT: Association study (especially the genome-wide association study) now has a key function in identification and characterization of disease-predisposing genetic variant(s), which customarily involve multiple single nucleotide polymorphisms (SNPs) in a candidate region or across the genome. Case-control association design remains the most popular and a challenging issue in the statistical analysis is the optimal use of all information contained in these SNPs. Previous approaches often treated gene-gene interaction as deviation from additive genetic effects or replaced it with SNP-SNP interaction. However, these approaches are limited for their failure of consideration of gene-gene interaction or gene-gene co-association at gene level. Although the co-association of the SNPs within a candidate

SUBMITTER: Peng Q 

PROVIDER: S-EPMC2987308 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature