Genome-wide SNP analysis reveals no gain in power for association studies of common variants in the Finnish Saami.

ABSTRACT: The Saami from Fennoscandia are believed to represent an ancient, genetically isolated population with no evidence of population expansion. Theoretical work has indicated that under this demographic scenario, extensive linkage disequilibrium (LD) is generated by genetic drift. Therefore, it has been suggested that the Saami would be particularly suited for genetic association studies, offering a substantial power advantage and allowing more economic study designs. However, no study has yet assessed this claim. As part of a GWAS for a complex trait, we evaluated the relative power for association studies of common variants in the Finnish Saami. LD patterns in the Saami were very similar to those in the non-African HapMap reference panels. Haplotype diversity was reduced and, on average, lev

SUBMITTER: Huyghe JR 

PROVIDER: S-EPMC2987317 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature