Replication of past candidate loci for common diseases and phenotypes in 100 genome-wide association studies.

ABSTRACT: Genome-wide association studies (GWASs) have created a paradigm shift in discovering genetic associations for common diseases and phenotypes, but it is unclear whether the thousands of candidate genetic association studies performed in the pre-GWAS era had found any reliable associations for common diseases and phenotypes. We aimed to systematically evaluate whether loci proposed to harbor candidate associations before the advent of GWASs are replicated in GWASs. The GWAS data published through August, 2008 and included in the NHGRI catalog were screened and variants in candidate loci were selected on the basis of statistical significance (P<0.05) to create a list of independent, non-redundant associations. Altogether, 159 articles on GWASs were evaluated, 100 of which addressed past propo

SUBMITTER: Siontis KC 

PROVIDER: S-EPMC2987361 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature