Dampened activity of E2F1-DP and Myb-MuvB transcription factors in Drosophila endocycling cells.

ABSTRACT: The endocycle is a variant cell cycle comprised of alternating gap (G) and DNA synthesis (S) phases (endoreplication) without mitosis (M), which results in DNA polyploidy and large cell size. Endocycles occur widely in nature, but much remains to be learned about the regulation of this modified cell cycle. Here, we compared gene expression profiles of mitotic cycling larval brain and disc cells with the endocycling cells of fat body and salivary gland of the Drosophila larva. The results indicated that many genes that are positively regulated by the heterodimeric E2F1-DP or Myb-MuvB complex transcription factors are expressed at lower levels in endocycling cells. Many of these target genes have functions in M phase, suggesting that dampened E2F1 and Myb activity promote endocycles. Many ot

SUBMITTER: Maqbool SB 

PROVIDER: S-EPMC2987441 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature