Cardiomyogenesis in the adult human heart.

ABSTRACT:

Rationale

The ability of the human heart to regenerate large quantities of myocytes remains controversial, and the extent of myocyte renewal claimed by different laboratories varies from none to nearly 20% per year.

Objective

To address this issue, we examined the percentage of myocytes, endothelial cells, and fibroblasts labeled by iododeoxyuridine in postmortem samples obtained from cancer patients who received the thymidine analog for therapeutic purposes. Additionally, the potential contribution of DNA repair, polyploidy, and cell fusion to the measurement of myocyte regeneration was determined.

Methods and results

The fraction of myocytes labeled by iododeoxyuridine ranged from 2.5% to 46%, and similar values were found in fibroblasts and endothelial cells. An av

SUBMITTER: Kajstura J 

PROVIDER: S-EPMC2987602 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature