Vitamin C and E supplementation to prevent spontaneous preterm birth: a randomized controlled trial.

ABSTRACT:

Objective

To estimate whether maternally administered vitamins C and E lower the risk of spontaneous preterm birth.

Methods

This is a secondary analysis of a randomized, double-masked, placebo-controlled trial in nulliparous women at low-risk administered 1,000 mg vitamin C and 400 international units vitamin E or placebo daily from 9 to 16 weeks of gestation until delivery. Outcomes include preterm birth attributable to premature rupture of membranes (PROM) and total spontaneous preterm births (spontaneous preterm birth attributable to PROM or spontaneous labor).

Results

Of the 10,154 women randomized, outcome data were available for 9,968 (4,992 vitamin group and 4,976 placebo group). A total of 1,038 women (10.4%) delivered preterm, of whom 698 (7.0%) had spontaneo

SUBMITTER: Hauth JC 

PROVIDER: S-EPMC2987650 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature