Untangling the Interplay between Epidemic Spread and Transmission Network Dynamics.

ABSTRACT: The epidemic spread of infectious diseases is ubiquitous and often has a considerable impact on public health and economic wealth. The large variability in the spatio-temporal patterns of epidemics prohibits simple interventions and requires a detailed analysis of each epidemic with respect to its infectious agent and the corresponding routes of transmission. To facilitate this analysis, we introduce a mathematical framework which links epidemic patterns to the topology and dynamics of the underlying transmission network. The evolution, both in disease prevalence and transmission network topology, is derived from a closed set of partial differential equations for infections without allowing for recovery. The predictions are in excellent agreement with complementarily conducted agent-based

SUBMITTER: Kamp C 

PROVIDER: S-EPMC2987842 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature