Ovine serum biomarkers of early and late phase scrapie.

ABSTRACT:

Background

Transmissible spongiform encephalopathies are fatal neurodegenerative disease occurring in animals and humans for which no ante-mortem diagnostic test in biological fluids is available. In such pathologies, detection of the pathological form of the prion protein (i.e., the causative factor) in blood is difficult and therefore identification of new biomarkers implicated in the pathway of prion infection is relevant.

Methods

In this study we used the SELDI-TOF MS technology to analyze a large number of serum samples from control sheep and animals with early phase or late phase scrapie. A few potential low molecular weight biomarkers were selected by statistical methods and, after a training analysis, a protein signature pattern, which discriminates between early pha

SUBMITTER: Batxelli-Molina I 

PROVIDER: S-EPMC2988006 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature