Breakpoint structure of the Anopheles gambiae 2Rb chromosomal inversion.

ABSTRACT:

Background

Alternative arrangements of chromosome 2 inversions in Anopheles gambiae are important sources of population structure, and are associated with adaptation to environmental heterogeneity. The forces responsible for their origin and maintenance are incompletely understood. Molecular characterization of inversion breakpoints provides insight into how they arose, and provides the basis for development of molecular karyotyping methods useful in future studies.

Methods

Sequence comparison of regions near the cytological breakpoints of 2Rb allowed the molecular delineation of breakpoint boundaries. Comparisons were made between the standard 2R+b arrangement in the An. gambiae PEST reference genome and the inverted 2Rb arrangements in the An. gambiae M and S genome assemb

SUBMITTER: Lobo NF 

PROVIDER: S-EPMC2988034 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature