Long-term mortality in HIV patients virally suppressed for more than three years with incomplete CD4 recovery: a cohort study.

ABSTRACT:

Background

The mortality in patients with persistent low CD4 count despite several years of HAART with sustained viral suppression is poorly documented. We aimed to identify predictors for inadequate CD4 cell recovery and estimate mortality in patients with low CD4 count but otherwise successful HAART.

Method

In a nationwide cohort of HIV patients we identified all individuals who started HAART before 1 January 2005 with CD4 cell count ≤ 200 cells/μL and experienced three years with sustained viral suppression. Patients were categorized according to CD4 cell count after the three years suppressed period (≤ 200 cells/μL; immunological non-responders (INRs), >200 cells/μL; immunological responders (IRs)). We used logistic regression and Kaplan-Meier analysis to estimated risk

SUBMITTER: Engsig FN 

PROVIDER: S-EPMC2988053 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature