Altered function and connectivity of the medial frontal cortex in pediatric obsessive-compulsive disorder.

ABSTRACT:

Background

Exaggerated concern for correct performance has been linked to hyperactivity of the medial frontal cortex (MFC) in adult obsessive-compulsive disorder (OCD), but the role of the MFC during the early course of illness remains poorly understood. We tested whether hyperactive MFC-based performance monitoring function relates to altered MFC connectivity within task control and default mode networks in pediatric patients.

Methods

Eighteen pairs of OCD and matched healthy youth underwent functional magnetic resonance imaging during performance monitoring and at rest. Task-related hyperactivations in the posterior and ventral MFC were used as seeds for connectivity analyses during task and resting state.

Results

In posterior MFC, patients showed greater activation

SUBMITTER: Fitzgerald KD 

PROVIDER: S-EPMC2988474 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature