Development of a single base extension method to resolve Y chromosome haplogroups in sub-Saharan African populations.

ABSTRACT:

Background

The ability of the Y chromosome to retain a record of its evolution has seen it become an essential tool of molecular anthropology. In the last few years, however, it has also found use in forensic genetics, providing information on the geographic origin of individuals. This has been aided by the development of efficient screening methods and an increased knowledge of geographic distribution. In this study, we describe the development of single base extension assays used to resolve 61 Y chromosome haplogroups, mainly within haplogroups A, B and E, found in Africa.

Results

Seven multiplex assays, which incorporated 60 Y chromosome markers, were developed. These resolved Y chromosomes to 61 terminal branches of the major African haplogroups A, B and E, while also in

SUBMITTER: Naidoo T 

PROVIDER: S-EPMC2988483 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature