Genome-wide analysis of genetic loci associated with Alzheimer disease.

ABSTRACT:

Context

Genome-wide association studies (GWAS) have recently identified CLU, PICALM, and CR1 as novel genes for late-onset Alzheimer disease (AD).

Objectives

To identify and strengthen additional loci associated with AD and confirm these in an independent sample and to examine the contribution of recently identified genes to AD risk prediction in a 3-stage analysis of new and previously published GWAS on more than 35,000 persons (8371 AD cases).

Design, setting, and participants

In stage 1, we identified strong genetic associations (P < 10(-3)) in a sample of 3006 AD cases and 14,642 controls by combining new data from the population-based Cohorts for Heart and Aging Research in Genomic Epidemiology consortium (1367 AD cases [973 incident]) with previously reported re

SUBMITTER: Seshadri S 

PROVIDER: S-EPMC2989531 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature