F 15845, a new blocker of the persistent sodium current prevents consequences of hypoxia in rat femoral artery.

ABSTRACT:

Background and purpose

The persistent sodium current is involved in myocardial ischaemia and is selectively inhibited by the newly described 3-(R)-[3-(2-methoxyphenylthio-2-(S)-methylpropyl]amino-3,4-dihydro-2H-1,5-benzoxathiepine bromhydrate (F 15845). Here, we describe the pharmacological profile of F 15845 against the effects of hypoxia in femoral arteries in vitro.

Experimental approach

Isometric tension measurement of rat isolated femoral arteries was used to characterize the protective effect of F 15845 against contraction of the vessels induced by veratrine (100 microg.mL(-1)) or hypoxia.

Key results

Rat femoral artery expressed the Na(v)1.5 channel isoform. When exposed to veratrine (100 microg.mL(-1)), vessels developed a rapid and strong contraction that was

SUBMITTER: Bocquet A 

PROVIDER: S-EPMC2989591 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature