Induction of a novel cation current in cardiac ventricular myocytes by flufenamic acid and related drugs.

ABSTRACT:

Background and purpose

Interest in non-selective cation channels has increased recently following the discovery of transient receptor potential (TRP) proteins, which constitute many of these channels.

Experimental approach

We used the whole-cell patch-clamp technique on isolated ventricular myocytes to investigate the effect of flufenamic acid (FFA) and related drugs on membrane ion currents.

Key results

With voltage-dependent and other ion channels inhibited, cells that were exposed to FFA, N-(p-amylcinnamoyl)anthranilic acid (ACA), ONO-RS-082 or niflumic acid (NFA) responded with an increase in currents. The induced current reversed at +38 mV, was unaffected by lowering extracellular Cl(-) concentration or by the removal of extracellular Ca(2+) and Mg(2+), and its i

SUBMITTER: Macianskiene R 

PROVIDER: S-EPMC2989592 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature