Attenuated sex steroid receptor expression in fallopian tube of women with ectopic pregnancy.

ABSTRACT:

Context

Sex steroid hormone receptor (SHR) dynamics are well-documented in human endometrium but have not been comprehensively studied in Fallopian tube (FT).

Objective

The aim of the study was to compare expression patterns and hormonal regulation of SHR in FT with that described in endometrium and to determine whether SHR expression is altered in FT of women with ectopic pregnancy (EP).

Design

Tissue was analyzed and cultured.

Patients or other participants

Women undergoing surgery for benign gynecological conditions (n = 14) and EP (n = 6) participated in the study.

Interventions

Quantitative RT-PCR and immunohistochemistry were used to determine SHR mRNA expression and protein localization, respectively. SHR levels were measured in tubal explant cult

SUBMITTER: Horne AW 

PROVIDER: S-EPMC2989877 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature