Pregabalin versus gabapentin in partial epilepsy: a meta-analysis of dose-response relationships.

ABSTRACT:

Background

To compare the efficacy of pregabalin and gabapentin at comparable effective dose levels in patients with refractory partial epilepsy.

Methods

Eight randomized placebo controlled trials investigating the efficacy of pregabalin (4 studies) and gabapentin (4 studies) over 12 weeks were identified with a systematic literature search. The endpoints of interest were "responder rate" (where response was defined as at least a 50% reduction from baseline in the number of seizures) and "change from baseline in seizure-free days over the last 28 days (SFD)". Results of all trials were analyzed using an indirect comparison approach with placebo as the common comparator. The base-case analysis used the intention-to-treat last observation carried forward method. Two sensitivit

SUBMITTER: Delahoy P 

PROVIDER: S-EPMC2989949 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature