Differential effects of uridine adenosine tetraphosphate on purinoceptors in the rat isolated perfused kidney.

ABSTRACT:

Background and purpose

Purinergic signalling plays an important role in vascular tone regulation in humans. We have identified uridine adenosine tetraphosphate (Up(4)A) as a novel and highly potent endothelial-derived contracting factor. Up(4)A induces strong vasoconstrictive effects in the renal vascular system mainly by P2X(1) receptor activation. However, other purinoceptors are also involved and were analysed here.

Experimental approach

The rat isolated perfused kidney was used to characterize vasoactive actions of Up(4)A.

Key results

After desensitization of the P2X(1) receptor by α,β-methylene ATP (α,β-meATP), Up(4)A showed dose-dependent P2Y(2)-mediated vasoconstriction. Continuous perfusion with Up(4)A evoked a biphasic vasoconstrictor effect: there was a stro

SUBMITTER: Tolle M 

PROVIDER: S-EPMC2990153 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature