Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception.

ABSTRACT:

Background and purpose

Temperature-sensitive transient receptor potential ion channels (thermoTRPs) expressed in primary sensory neurons and skin keratinocytes play a crucial role as peripheral pain detectors. Many natural and synthetic ligands have been found to act on thermoTRPs, but little is known about endogenous compounds that inhibit these TRPs. Here, we asked whether resolvin D1 (RvD1), a naturally occurring anti-inflammatory and pro-resolving lipid molecule is able to affect the TRP channel activation.

Experimental approach

We examined the effect of RvD1 on the six thermoTRPs using Ca(2+) imaging and whole cell electrophysiology experiments using the HEK cell heterologous expression system, cultured sensory neurons and HaCaT keratinocytes. We also checked changes in

SUBMITTER: Bang S 

PROVIDER: S-EPMC2990166 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature