Genetic associations of brain structural networks in schizophrenia: a preliminary study.

ABSTRACT:

Background

Schizophrenia is a complex genetic disorder, with multiple putative risk genes and many reports of reduced cortical gray matter. Identifying the genetic loci contributing to these structural alterations in schizophrenia (and likely also to normal structural gray matter patterns) could aid understanding of schizophrenia's pathophysiology. We used structural parameters as potential intermediate illness markers to investigate genomic factors derived from single nucleotide polymorphism (SNP) arrays.

Method

We used research quality structural magnetic resonance imaging (sMRI) scans from European American subjects including 33 healthy control subjects and 18 schizophrenia patients. All subjects were genotyped for 367 SNPs. Linked sMRI and genetic (SNP) components were e

SUBMITTER: Jagannathan K 

PROVIDER: S-EPMC2990476 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature