Ontology highlight
ABSTRACT:
SUBMITTER: Guo H
PROVIDER: S-EPMC2990499 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Guo Huili H Ingolia Nicholas T NT Weissman Jonathan S JS Bartel David P DP
Nature 20100801 7308
MicroRNAs (miRNAs) are endogenous approximately 22-nucleotide RNAs that mediate important gene-regulatory events by pairing to the mRNAs of protein-coding genes to direct their repression. Repression of these regulatory targets leads to decreased translational efficiency and/or decreased mRNA levels, but the relative contributions of these two outcomes have been largely unknown, particularly for endogenous targets expressed at low-to-moderate levels. Here, we use ribosome profiling to measure th ...[more]