Src tyrosine kinase regulates adhesion and chemotaxis in Waldenstrom macroglobulinemia.

ABSTRACT:

Purpose

Waldenstrom macroglobulinemia is a lymphoplasmacytic lymphoma characterized by widespread involvement of the bone marrow. Despite different options of therapy, Waldenstrom macroglobulinemia is still incurable. Src tyrosine kinase has been shown to play a central role in the regulation of a variety of biological processes, such as cell proliferation, migration, adhesion, and survival in solid tumors. We sought to determine whether the protein tyrosine kinase Src regulates adhesion, migration, and survival in Waldenstrom macroglobulinemia.

Experimental design

We tested the expression of Src tyrosine kinase in Waldenstrom macroglobulinemia and normal cells, and the effect of the specific Src inhibitor AZD0530 on the adhesion, migration, cell cycle, and survival of a Wal

SUBMITTER: Ngo HT 

PROVIDER: S-EPMC2990685 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature