Sequence motifs in MADS transcription factors responsible for specificity and diversification of protein-protein interaction.

ABSTRACT: Protein sequences encompass tertiary structures and contain information about specific molecular interactions, which in turn determine biological functions of proteins. Knowledge about how protein sequences define interaction specificity is largely missing, in particular for paralogous protein families with high sequence similarity, such as the plant MADS domain transcription factor family. In comparison to the situation in mammalian species, this important family of transcription regulators has expanded enormously in plant species and contains over 100 members in the model plant species Arabidopsis thaliana. Here, we provide insight into the mechanisms that determine protein-protein interaction specificity for the Arabidopsis MADS domain transcription factor family, using an integrated co

SUBMITTER: van Dijk AD 

PROVIDER: S-EPMC2991254 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature