HapX positively and negatively regulates the transcriptional response to iron deprivation in Cryptococcus neoformans.

ABSTRACT: The fungal pathogen Cryptococcus neoformans is a major cause of illness in immunocompromised individuals such as AIDS patients. The ability of the fungus to acquire nutrients during proliferation in host tissue and the ability to elaborate a polysaccharide capsule are critical determinants of disease outcome. We previously showed that the GATA factor, Cir1, is a major regulator both of the iron uptake functions needed for growth in host tissue and the key virulence factors such as capsule, melanin and growth at 37°C. We are interested in further defining the mechanisms of iron acquisition from inorganic and host-derived iron sources with the goal of understanding the nutritional adaptation of C. neoformans to the host environment. In this study, we investigated the roles of the HAP3 and HA

SUBMITTER: Jung WH 

PROVIDER: S-EPMC2991262 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature