Risk factors for acute kidney injury following orthotopic liver transplantation: the impact of changes in renal function while patients await transplantation.

ABSTRACT:

Background

Acute kidney injury (AKI) occurs commonly in the setting of orthotopic liver transplantation (OLT). To date, the correlation between AKI post-OLT and pre-operative changes in renal function has not been rigorously examined.

Methods

To determine the impact of pre-OLT changes in renal function on AKI post-OLT, as well as to identify risk factors for AKI, we analyzed the prospectively maintained NIDDK Liver Transplantation Database, which includes patients who received their first OLT between April 15, 1990, and June 30, 1994. We used the AKI Network definition of AKI.

Results

Surprisingly, univariate analysis revealed that worsening renal function while awaiting OLT was protective to the development of AKI post-OLT. Independent predictors of AKI were increase

SUBMITTER: Iglesias JI 

PROVIDER: S-EPMC2991287 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature