Model of the complex of Parathyroid hormone-2 receptor and Tuberoinfundibular peptide of 39 residues.

ABSTRACT:

Background

We aim to propose interactions between the parathyroid hormone-2 receptor (PTH2R) and its ligand the tuberoinfundibular peptide of 39 residues (TIP39) by constructing a homology model of their complex. The two related peptides parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrP) are compared with the complex to examine their interactions.

Findings

In the model, the hydrophobic N-terminus of TIP39 is buried in a hydrophobic part of the central cavity between helices 3 and 7. Comparison of the peptide sequences indicates that the main discriminator between the agonistic peptides TIP39 and PTH and the inactive PTHrP is a tryptophan-phenylalanine replacement. The model indicates that the smaller phenylalanine in PTHrP does not completely occupy th

SUBMITTER: Abraham-Nordling M 

PROVIDER: S-EPMC2991341 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature