Leukocyte chemotactic factor 2 (LECT2)-associated renal amyloidosis: a case series.

ABSTRACT:

Background

Renal amyloidosis is characterized by the pathologic deposition within glomeruli and/or interstitium of congophilic fibrils, most often composed of either immunoglobulin light chains or serum amyloid A-related protein and, less commonly, mutated forms of apolipoproteins AI or AII, lysozyme, fibrinogen, gelsolin, or transthyretin.

Study design

Case series.

Setting & participants

10 patients with renal amyloidosis who had an amyloidogenic protein that was not identified using routine immunohistochemistry.

Outcomes

Clinical, pathologic, biochemical, and genetic characteristics.

Measurements

Tandem mass spectrometry was used to analyze fibrils extracted from sections of formalin-fixed paraffin-embedded amyloid-containing kidney biopsy specimen blo

SUBMITTER: Murphy CL 

PROVIDER: S-EPMC2991509 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature