Effect of remote ischemic preconditioning on acute kidney injury in nondiabetic patients undergoing coronary artery bypass graft surgery: a secondary analysis of 2 small randomized trials.

ABSTRACT:

Background

Novel treatment strategies are required to reduce the development of acute kidney injury (AKI) in patients undergoing cardiac surgery. In this respect, remote ischemic preconditioning (RIPC), a phenomenon in which transient nonlethal ischemia applied to an organ or tissue protects another organ or tissue from subsequent lethal ischemic injury, is a potential renoprotective strategy.

Study design

Secondary analysis of 2 randomized trials.

Setting & participants

78 consenting selected nondiabetic patients in a university teaching hospital undergoing elective coronary artery bypass graft (CABG) surgery recruited to 2 previously reported randomized studies.

Intervention

RIPC consisted of three 5-minute cycles of right forearm ischemia, induced by inflati

SUBMITTER: Venugopal V 

PROVIDER: S-EPMC2991586 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature