Expression of the neuron-specific protein CHD5 is an independent marker of outcome in neuroblastoma.

ABSTRACT:

Background

The chromodomain, helicase DNA-binding protein 5 (CHD5) is a potential tumor suppressor gene located on chromosome 1p36, a region recurrently deleted in high risk neuroblastoma (NB). Previous data have shown that CHD5 mRNA is present in normal neural tissues and in low risk NB, nevertheless, the distribution of CHD5 protein has not been explored. The aim of this study was to investigate CHD5 protein expression as an immunohistochemical marker of outcome in NB. With this purpose, CHD5 protein expression was analyzed in normal neural tissues and neuroblastic tumors (NTs). CHD5 gene and protein expression was reexamined after induction chemotherapy in a subset of high risk tumors to identify potential changes reflecting tumor response.

Results

We provide evidence tha

SUBMITTER: Garcia I 

PROVIDER: S-EPMC2992029 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature