Conservation of shh cis-regulatory architecture of the coelacanth is consistent with its ancestral phylogenetic position.

ABSTRACT:

Background

The modern coelacanth (Latimeria) is the extant taxon of a basal sarcopterygian lineage and sister group to tetrapods. Apart from certain apomorphic traits, its morphology is characterized by a high degree of retention of ancestral vertebrate structures and little morphological change. An insight into the molecular evolution that may explain the unchanged character of Latimeria morphology requires the analysis of the expression patterns of developmental regulator genes and their cis-regulatory modules (CRMs).

Results

We describe the comparative and functional analysis of the sonic hedgehog (shh) genomic region of Latimeria menadoensis. Several putative enhancers in the Latimeria shh locus have been identified by comparisons to sarcopterygian and actinopterygian ex

SUBMITTER: Lang M 

PROVIDER: S-EPMC2992049 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature