APOE polymorphism is associated with lipid profile, but not with arterial stiffness in the general population.

ABSTRACT:

Background

Cardiovascular diseases (CVD) are the main cause of death and disability in developed countries. In most cases, the progress of CVD is influenced by environmental factors and multifactorial inheritance. The purpose of this study was to investigate the association between APOE genotypes, cardiovascular risk factors, and a non-invasive measure of arterial stiffness in the Brazilian population.

Methods

A total of 1493 urban Brazilian individuals were randomly selected from the general population of the Vitoria City Metropolitan area. Genetic analysis of the APOE polymorphism was conducted by PCR-RFLP and pulse wave velocity analyzed with a noninvasive automatic device.

Results

Age, gender, body mass index, triglycerides, creatinine, uric acid, blood glucose, b

SUBMITTER: Alvim RO 

PROVIDER: S-EPMC2992057 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature