Inhibition of core gene of HCV 3a genotype using synthetic and vector derived siRNAs.

ABSTRACT:

Background

Hepatitis C virus (HCV) is a major causative agent of liver associated diseases throughout the world, with genotype 3a responsible for most of the cases in Pakistan. Due to the limited efficiency of current therapy, RNA interference (RNAi) a novel regulatory and powerful silencing approach for molecular therapeutics through a sequence-specific RNA degradation process represents an alternative option.

Results

The current study was purposed to assess and explore the possibility of RNAi to silence the HCV-3a Core gene expression, which play complex role in regulation of cell growth and host genes expression essential for infectivity and disease progression. To identify the potent siRNA target sites, 5 small interfering RNAs (siRNAs) against Core gene were designed an

SUBMITTER: Khaliq S 

PROVIDER: S-EPMC2992066 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature