Serglycin-independent release of active mast cell proteases in response to Toxoplasma gondii infection.

ABSTRACT: Earlier studies identified serglycin proteoglycan and its heparin chains to be important for storage and activity of mast cell proteases. However, the importance of serglycin for secretion and activity of mast cell proteases in response to parasite infection has been poorly investigated. To address this issue, we studied the effects on mast cell proteases in serglycin-deficient and wild type mice after peritoneal infection with the obligate intracellular parasite Toxoplasma gondii. In line with previous results, we found severely reduced levels of cell-bound mast cell proteases in both noninfected and infected serglycin-deficient mice. However, serglycin-deficient mice secreted mast cell proteases at wild type levels at the site of infection, and enzymatic activities associated with mast c

SUBMITTER: Sawesi O 

PROVIDER: S-EPMC2992234 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature