Linkage analysis of obesity phenotypes in pre- and post-menopausal women from a United States mid-western population.

ABSTRACT:

Background

Obesity has a strong genetic influence, with some variants showing stronger associations among women than men. Women are also more likely to distribute weight in the abdomen following menopause. We investigated whether genetic loci link with obesity-related phenotypes differently by menopausal status.

Methods

We performed univariate and bivariate linkage analysis for the phenotypes of body mass index (BMI), waist (W) and hip (H) circumferences (WC, HC), and WH ratio (WHR) separately among 172 pre-menopausal and 405 post-menopausal women from 90 multigenerational families using a genome scan with 403 microsatellite markers. Bivariate analysis used pair-wise combinations of obesity phenotypes to detect linkage at loci with pleiotropic effects for genetically correla

SUBMITTER: Kelemen LE 

PROVIDER: S-EPMC2992490 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature