Disruption of hepatic leptin signaling protects mice from age- and diet-related glucose intolerance.

ABSTRACT:

Objective

The liver plays a critical role in integrating and controlling glucose metabolism. Thus, it is important that the liver receive and react to signals from other tissues regarding the nutrient status of the body. Leptin, which is produced and secreted from adipose tissue, is a hormone that relays information regarding the status of adipose depots to other parts of the body. Leptin has a profound influence on glucose metabolism, so we sought to determine if leptin may exert this effect in part through the liver.

Research design and methods

To explore this possibility, we created mice that have disrupted hepatic leptin signaling using a Cre-lox approach and then investigated aspects of glucose metabolism in these animals.

Results

The loss of hepatic leptin signa

SUBMITTER: Huynh FK 

PROVIDER: S-EPMC2992763 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature