Effects of PNPLA3 on liver fat and metabolic profile in Hispanic children and adolescents.

ABSTRACT:

Objective

A genome-wide study of adults identified a variant of PNPLA3 (rs738409) associated with ∼twofold higher liver fat. The purpose of this study was to examine the influence of PNPLA3 genotype on liver fat and other related metabolic outcomes in obese Hispanic children and adolescents.

Research design and methods

Three hundred and twenty-seven Hispanics aged 8-18 years were genotyped for rs738409. One hundred and eighty-eight subjects had measures of visceral (VAT) and subcutaneous (SAT) adipose tissue volume and hepatic (HFF) and pancreatic (PFF) fat fraction by magnetic resonance imaging. One hundred and thirty-nine subjects did not have HFF measures but had extensive measures of insulin sensitivity and fasting lipids.

Results

Liver fat in GG subjects was 1.7

SUBMITTER: Goran MI 

PROVIDER: S-EPMC2992774 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature