Cause-specific mortality trends in a large population-based cohort with long-standing childhood-onset type 1 diabetes.

ABSTRACT:

Objective

Little is known concerning the primary cause(s) of mortality in type 1 diabetes responsible for the excess mortality seen in this population.

Research design and methods

The Allegheny County (Pennsylvania) childhood-onset (age < 18 years) type 1 diabetes registry (n = 1,075) with diagnosis from 1965 to 1979 was used to explore patterns in cause-specific mortality. Cause of death was determined by a mortality classification committee of at least three physician epidemiologists, based on the death certificate and additional records surrounding the death.

Results

Vital status for 1,043 (97%) participants was ascertained as of 1 January 2008, revealing 279 (26.0%) deaths overall (141 females and 138 males). Within the first 10 years after diagnosis, the leading

SUBMITTER: Secrest AM 

PROVIDER: S-EPMC2992785 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature