GABA(A) receptors in the dorsal raphe nucleus of mice: escalation of aggression after alcohol consumption.

ABSTRACT:

Rationale

The dorsal raphé nucleus (DRN), the origin for serotonin (5-HT) in forebrain areas, has been implicated in the neural control of escalated aggression. Gamma aminobutyric acid type-A (GABA(A)) and type-B (GABA(B)) receptors are expressed in the DRN and modulate 5-HT neuronal activity, and both play a role in the behavioral effect of alcohol.

Objective

The purpose of this study is to examine the interaction between drugs acting on GABA receptors in the DRN and alcohol in their effects on aggressive behaviors.

Method

Male CFW mice, housed with a female, were trained to self-administer ethanol (1.0 g/kg) or water via an operant conditioning panel in their home cage. Immediately after they drank either ethanol or water, the animals were microinfused with a GABAer

SUBMITTER: Takahashi A 

PROVIDER: S-EPMC2992972 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature