Prematurity, chorioamnionitis, and the development of recurrent wheezing: a prospective birth cohort study.

ABSTRACT:

Background

Prematurity (< 37 weeks) has been inconsistently associated with asthma and wheezing. Chorioamnionitis may promote both prematurity and inflammatory pathways in infants' airways.

Objective

To investigate the relationship of prematurity and chorioamnionitis with the development of early childhood recurrent wheezing.

Methods

The Boston Birth Cohort (n = 1096) were followed prospectively from birth to a mean age of 2.2 +/- 2 years. Perinatal and postnatal clinical data and placental pathology were collected. The primary outcome was recurrent wheezing (> or =2 physician documented episodes). Secondary outcomes included physician-diagnosed asthma, food allergy, and eczema. Preterm children were grouped by gestational age into moderately (33-36.9 weeks) and very

SUBMITTER: Kumar R 

PROVIDER: S-EPMC2993062 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature