Ontology highlight
ABSTRACT:
SUBMITTER: Pavri R
PROVIDER: S-EPMC2993080 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Pavri Rushad R Gazumyan Anna A Jankovic Mila M Di Virgilio Michela M Klein Isaac I Ansarah-Sobrinho Camilo C Resch Wolfgang W Yamane Arito A Reina San-Martin Bernardo B Barreto Vasco V Nieland Thomas J TJ Root David E DE Casellas Rafael R Nussenzweig Michel C MC
Cell 20101001 1
Activation-induced cytidine deaminase (AID) initiates antibody gene diversification by creating U:G mismatches. However, AID is not specific for antibody genes; Off-target lesions can activate oncogenes or cause chromosome translocations. Despite its importance in these transactions little is known about how AID finds its targets. We performed an shRNA screen to identify factors required for class switch recombination (CSR) of antibody loci. We found that Spt5, a factor associated with stalled R ...[more]