Molecular basis of coiled-coil oligomerization-state specificity.

ABSTRACT: Coiled coils are extensively and successfully used nowadays to rationally design multistranded structures for applications, including basic research, biotechnology, nanotechnology, materials science, and medicine. The wide range of applications as well as the important functions these structures play in almost all biological processes highlight the need for a detailed understanding of the factors that control coiled-coil folding and oligomerization. Here, we address the important and unresolved question why the presence of particular oligomerization-state determinants within a coiled coil does frequently not correlate with its topology. We found an unexpected, general link between coiled-coil oligomerization-state specificity and trigger sequences, elements that are indispensable for coile

SUBMITTER: Ciani B 

PROVIDER: S-EPMC2993330 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature