Growth signaling promotes chronological aging in budding yeast by inducing superoxide anions that inhibit quiescence.

ABSTRACT: Inhibition of growth signaling pathways protects against aging and age-related diseases in parallel with reduced oxidative stress. The relationships between growth signaling, oxidative stress and aging remain unclear. Here we report that in Saccharomyces cerevisiae, alterations in growth signaling pathways impact levels of superoxide anions that promote chronological aging and inhibit growth arrest of stationary phase cells in G0/G1. Factors that decrease intracellular superoxide anions in parallel with enhanced longevity and more efficient G0/G1 arrest include genetic inactivation of growth signaling pathways that inhibit Rim15p, which activates oxidative stress responses, and downregulation of these pathways by caloric restriction. Caloric restriction also reduces superoxide anions indep

SUBMITTER: Weinberger M 

PROVIDER: S-EPMC2993800 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature