Distinct DNA methylation profiles in ovarian serous neoplasms and their implications in ovarian carcinogenesis.

ABSTRACT:

Objective

The purpose of this study was to analyze DNA methylation profiles among different types of ovarian serous neoplasm, which is a task that has not been performed.

Study design

The Illumina beads array (Illumina Inc, San Diego, CA) was used to profile DNA methylation in enriched tumor cells that had been isolated from 75 benign and malignant serous tumor tissues and 6 tumor-associated stromal cell cultures.

Results

We found significantly fewer hypermethylated genes in high-grade serous carcinomas than in low-grade serous carcinoma and borderline tumors, which in turn had fewer hypermethylated genes than serous cystadenoma. Unsupervised analysis identified that serous cystadenoma, serous borderline tumor, and low-grade serous carcinomas tightly clustered togethe

SUBMITTER: Shih IeM 

PROVIDER: S-EPMC2993872 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature